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Published on: May 21, 2015
IL-6, IL-10 and TNF-α gene polymorphisms in preeclampsia: a case-control study in a Mexican population
Carlos Ernesto Mora Palazuelos1, Elsa Maribel Aguilar Medina1, Mariana Melisa Avendaño Felix1
1Universidad Autónoma de Sinaloa, Blvd. Miguel Tamayo Espinosa de los Monteros s/n, Torre de Rectoría Col. Desarrollo Urbano Tres Ríos, Culiacan, Mexico.
Objectives:
We focused our study on examining the genotype and allele frequency of IL-6 (rs1800795), TNF-α (rs1800629) and IL-10 (rs1800872) single nucleotide polymorphisms (SNP) on preeclampsia (PE) diagnosed Mexican pregnant women.
Material And Methods:
A case-control study was designed including 86 preeclampsia patients and 100 normotensives pregnancies from Women's Hospital of Culiacan, Mexico. Genotyping of IL-6, TNF-α and IL-10 was performed using TaqMan SNP Genotyping.
Results:
Not significant association was found between development of PE and genotypic (p > 0.05) and allelic (p > 0.05) frequencies of IL-6, TNF-α and IL-10 SNPs. Genotype distributions of IL-6 (p = 0.599), TNF-α (p = 0.721) and IL-10 (p = 0.761) polymorphisms in the two groups were in agreement with Hardy-Weinberg equilibrium.
Conclusions:
According to the findings, the IL-6, TNF-α and IL-10 SNPs are not exponents of susceptibility to developing PE.
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