Related Experiment Video

Updated: Jul 13, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.3K

Effect of Resveratrol on Endothelial Function in Patients with CKD and Diabetes: A Randomized Controlled Trial

Colin J Gimblet1, Nicholas T Kruse2, Katharine Geasland3

  • 1Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa.

Clinical Journal of the American Society of Nephrology : CJASN
|October 16, 2023
PubMed

Insights

Resveratrol supplementation improved endothelial function in patients with chronic kidney disease (CKD) and diabetes. This finding suggests a potential benefit for cardiovascular health in this high-risk population.

Area of Science:

  • Cardiovascular Research
  • Nephrology
  • Endocrinology

Background:

  • Patients with chronic kidney disease (CKD) and diabetes face elevated cardiovascular disease (CVD) risk due to impaired endothelial function.
  • Resveratrol, a cardioprotective compound, may enhance endothelial function and reduce CVD burden in this population.

Purpose of the Study:

  • To investigate the effects of resveratrol supplementation on endothelial function in patients with stage 3 CKD and diabetes.

Main Methods:

  • A randomized, double-blind, placebo-controlled, crossover study involving 28 adults (84% men, aged 68±7 years) with stage 3 CKD and diabetes.
  • Participants received 400 mg/d of resveratrol or placebo for 6 weeks.
  • Endothelial function was assessed using brachial artery flow-mediated dilation (FMD).

Main Results:

  • Resveratrol supplementation significantly increased flow-mediated dilation compared to placebo (ratio of geometric mean changes: 1.43; 95% CI: 1.15 to 1.77; P=0.001).
  • No significant changes were observed in estimated glomerular filtration rate (eGFR), hemoglobin A1c, blood pressure, or nitroglycerin-mediated dilation.
  • The improvement in FMD appeared independent of changes in traditional cardiovascular risk factors.

Conclusions:

  • Resveratrol supplementation effectively improved endothelial function in individuals with both CKD and diabetes.
  • These findings highlight resveratrol's potential as a therapeutic agent to mitigate cardiovascular risk in this vulnerable patient group.
Abstract

More Related Videos

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

600
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.1K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
18
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
21
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
14
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
400
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
9