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Updated: Jul 13, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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A Novel RHCE*cE (c.827C>A) Allele, Containing the Single-Nucleotide Change, Encodes Altered c/E Antigens

Chang-Lin Wu, Pin Yi, Bing-Di Tang

    Clinical Laboratory
    |October 16, 2023
    PubMed

    Insights

    The complex RH blood group system has over 50 antigens. Molecular methods precisely characterize variant RhCE alleles causing altered antigen expression, aiding transfusion services.

    Area of Science:

    • Immunogenetics
    • Hematology
    • Molecular Biology

    Background:

    • The RH blood group system is highly complex, featuring over 50 antigens.
    • Hundreds of RhCE variant alleles exist, leading to weakened or partial RhCE antigen expression.
    • Genetic mechanisms include gene conversion between RHD and RHCE, and missense mutations.

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