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Updated: Jul 13, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Organophotocatalytic Alkene Reduction Using Water as a Hydrogen Donor
Wen-Jie Kang1, Yuze Pan1, Aishun Ding2
1Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, P. R. China.
Abstract:
The chemical activation and functionalization of water are considered an ideal method for converting earth-abundant sources into valuable chemicals. Here, we show that a non-activated free water molecule can be applied directly as a hydrogen donor to achieve the carbanion-mediated alkene reduction with 9-HTXTF serving as an organophotocatalyst. Notably, direct syntheses of high-value-added drugs and bioactive molecules are readily achieved by utilizing plentiful energy and an earth-abundant resource, showcasing the usefulness of the protocol in chemical synthesis.
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