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Updated: Jun 3, 2025
Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
Published on: April 24, 2018
Visible Light-Induced Divergent Deoxygenation/Hydroxymethylation of Pyridine N-Oxides
Changhao Feng1, Hao Guo1, Aishun Ding1
1Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, PR China.
Abstract:
This study explores the deoxygenation of pyridine N-oxides and presents a one-step photoredox method for the direct synthesis of 2-hydroxymethylated pyridines from pyridine N-oxides. Mechanism studies elucidate the role of the catalyst and provide evidence of the possible electron transfer process and the formation of key radicals. A range of pyridine derivatives, particularly 2-hydroxymethyl-substituted pyridines, which may be difficult to obtain, can be synthesized in a single step.
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