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Test-retest repeatability in macular retinal oximetry.

Jennyffer D Smith1, Kelly Bisignano1, Wendy W Harrison1

  • 1Department of Optometry, University of Houston College of Optometry, Houston, TX, USA.

Clinical & Experimental Optometry
|October 16, 2023
PubMed
Summary
This summary is machine-generated.

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The Zilia oximeter shows good test-retest repeatability for macular oxygen saturation in healthy adults. Multiple readings may be necessary for precise retinal oximetry measurements.

Area of Science:

  • Ophthalmology
  • Medical Devices
  • Physiology

Background:

  • Evaluating retinal macular oxygen saturation in healthy individuals is crucial for understanding vascular diseases like diabetes.
  • Localised retinal oximetry provides insights into macular health.

Purpose of the Study:

  • To assess the test-retest repeatability of the Zilia Oximeter for retinal oximetry in healthy adults.
  • To evaluate macular oxygen saturation measurements in different racial groups aged 18-40 years.

Main Methods:

  • Twenty-seven healthy adults (mean age 26.3 years) underwent retinal oximetry using the Zilia device.
  • Measurements were taken at four macular locations, repeated twice on the same day and again 1-2 weeks later.
  • Intraclass correlation, Bland-Altman repeatability coefficient, and coefficient of variation were used for analysis.
Keywords:
Maculamicrovasculatureoximetryrepeatabilityretinopathy

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Last Updated: Jul 13, 2025

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Main Results:

  • The average intraclass correlation across three measurement times was 0.78.
  • The averaged intrasubject repeatability coefficient was 8.4, with a coefficient of variation of 5.4%.

Conclusions:

  • The Zilia oximeter demonstrates good test-retest repeatability for macular oxygen saturation measurements.
  • While repeatable, clinicians may need to obtain multiple readings to ensure accuracy in retinal oximetry.