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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

538
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Updated: Jul 13, 2025

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Alpha-Emitter Radium-223 Induces STING-Dependent Pyroptosis to Trigger Robust Antitumor Immunity.

Mengdie Yang1,2, Haipeng Liu3, Jingjing Lou4

  • 1Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.

Small (Weinheim an Der Bergstrasse, Germany)
|October 16, 2023
PubMed
Summary
This summary is machine-generated.

Radium-223 (223 Ra) triggers an immune response and pyroptosis, a form of cell death, to fight tumors. This alpha-emitter activates the STING pathway, enhancing antitumor immunity for new cancer therapies.

Keywords:
alpha-emitterimmunogenic cell deathpyroptosisradium-223stimulator of interferon genes (STING)

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Area of Science:

  • Oncology
  • Immunology
  • Radiochemistry

Background:

  • Radium-223 (223 Ra) is an alpha-emitter used for tumor eradication, primarily thought to act via DNA damage.
  • The immunogenic effects and specific cell death pathways induced by 223 Ra are not fully understood.

Purpose of the Study:

  • To investigate the immunogenic characteristics and cell death modalities induced by 223 Ra irradiation.
  • To elucidate the underlying molecular mechanisms of 223 Ra-mediated antitumor effects.

Main Methods:

  • Analysis of pro-inflammatory damage-associated molecular patterns (DAMPs) such as calreticulin, HMGB1, and HSP70.
  • Assessment of pyroptosis induction and its role in tumor progression.
  • Investigation of the stimulator of interferon genes (STING) pathway activation in response to 223 Ra.

Main Results:

  • 223 Ra irradiation induced pro-inflammatory DAMPs, indicating enhanced tumor immunogenicity.
  • Therapeutic 223 Ra demonstrated antitumor effects by triggering pyroptosis, an immunogenic cell death.
  • 223 Ra-induced DNA damage activated the STING pathway, which was crucial for pyroptosis, dendritic cell maturation, and T cell activation.

Conclusions:

  • 223 Ra induces antitumor immunity through pyroptosis and STING pathway activation.
  • STING plays a critical role in mediating the immunogenic effects of alpha-emitter 223 Ra.
  • These findings support the development of novel cancer therapeutics and combination therapies involving 223 Ra.