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Multiomic Approaches for Cancer Biomarker Discovery in Liquid Biopsies: Advances and Challenges
Paola Monterroso Diaz1,2, Ashton Leehans1, Prashanth Ravishankar1
1Namida Lab Inc., Fayetteville, AR, USA.
Biomarker Insights
|October 17, 2023
Summary
Liquid biopsies offer a non-invasive method for early cancer detection and monitoring. Integrating -omics technologies enhances precision oncology by personalizing treatments based on unique tumor biology.
Area of Science:
- Oncology
- Biochemistry
- Genetics
Background:
- Cancer is a major global health threat, necessitating early detection and effective treatments.
- Traditional tissue biopsies are invasive and may not fully represent tumor heterogeneity.
- Liquid biopsies provide a non-invasive alternative for cancer biomarker detection.
Purpose of the Study:
- To review advances and challenges in cancer liquid biopsies.
- To explore the integration of -omics technologies with liquid biopsies.
- To discuss applications across various liquid biopsy types.
Main Methods:
- Review of current literature on liquid biopsies and -omics integration.
- Analysis of different liquid biopsy sources (blood, tears, urine, sweat, saliva, CSF).
- Discussion of proteomic, genomic, and metabolomic applications.
Main Results:
- Liquid biopsies offer accessible and non-invasive cancer biomarker detection.
- -Omics technologies enable personalized treatment strategies (precision oncology).
- Various bodily fluids show potential as sources for liquid biopsies.
Conclusions:
- Liquid biopsies combined with -omics represent a significant advancement in cancer care.
- This approach facilitates early diagnosis, treatment monitoring, and relapse detection.
- Further research is needed to overcome challenges and optimize clinical application.
