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Related Experiment Video

Updated: Jul 13, 2025

In Vivo Two-Photon Microscopy of Single Nerve Endings in Skin
07:31

In Vivo Two-Photon Microscopy of Single Nerve Endings in Skin

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Fluorescence imaging of peripheral nerve function and structure.

Xiaoqi Yang1, Yumin Zhang2, Yadong Liu3

  • 1Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, Henan, China. fcczhoun@zzu.edu.cn.

Journal of Materials Chemistry. B
|October 17, 2023
PubMed
Summary
This summary is machine-generated.

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Fluorescence imaging aids peripheral nerve repair by visualizing nerve anatomy and internal transport function. This technique enables early detection of poor recovery, improving surgical outcomes and patient prognosis.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Peripheral nerve injuries are prevalent and can lead to severe, long-term functional deficits.
  • Despite inherent regenerative capabilities, complete recovery is often hindered by factors like age and injury type.
  • Current diagnostic and monitoring methods may not adequately capture nerve regeneration dynamics.

Purpose of the Study:

  • To review the application of fluorescence imaging in peripheral nerve repair.
  • To highlight the potential of fluorescence dyes in assessing nerve anatomy and function.
  • To explore how real-time imaging can improve surgical interventions and patient outcomes.

Main Methods:

  • Discussion of reported and potential peripheral nerve fluorescent dyes.

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  • Focus on dyes enabling visualization of nerve morphology and axoplasmic transport.
  • Review of intraoperative and functional neuroimaging techniques.

    • Main Results:

    • Fluorescence imaging offers dynamic, real-time visualization of nerve structures.
    • Axoplasmic transport-based neuroimaging facilitates objective assessment of nerve regeneration.
    • Early detection of impaired regeneration allows for timely intervention.

    Conclusions:

    • Fluorescence imaging presents a promising approach to overcome limitations in peripheral nerve repair.
    • Dynamic visualization aids in reducing iatrogenic injury during surgery.
    • Improved assessment of nerve function and anatomy can lead to better patient prognoses.