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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jul 1, 2026

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

Injectable Thermal-Protective Hydrogel Enables Curative Tumor Ablation via Chemo-Immunomodulation.

Peng Zhang1,2, Bowen Zheng3, Danfeng Peng1,2

  • 1School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, No. 66, Gongchang Road, Shenzhen, Guangdong 518107, PR China.

ACS Applied Materials & Interfaces
|June 30, 2026
PubMed
Summary

A novel injectable hydrogel enhances thermal ablation safety and efficacy for solid tumors. This material provides thermal insulation and controlled drug delivery, overcoming limitations and improving anti-tumor immune responses for better cancer treatment.

Keywords:
chemo-immunotherapyinjectable ultrasound-visible hydrogelmicroenvironment modulationthermal protectiontumor thermal ablation

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Area of Science:

  • Biomaterials Science
  • Cancer Therapy
  • Immunomodulation

Background:

  • Image-guided thermal ablation is limited by insufficient tumor destruction and thermal damage to surrounding tissues.
  • Sublethal heat at ablation margins can create an immunosuppressive tumor microenvironment, increasing recurrence risk.

Purpose of the Study:

  • To develop an injectable hydrogel (MR@CaP@HA) for in situ thermal insulation and dual-responsive (pH/GSH) chemo-immunomodulatory drug delivery.
  • To overcome thermal safety and immune resistance barriers in thermal ablation therapies.

Main Methods:

  • Development of MR@CaP@HA hydrogel with thermal insulation properties.
  • Utilizing a disulfide-cross-linked hyaluronic acid network for glutathione (GSH)-dependent drug release.
  • Dual-responsive (pH/GSH) delivery of mitoxantrone (MIT) and resiquimod (R848) via MR@CaP nanoparticles.

Main Results:

  • MR@CaP@HA hydrogel provided 5-10 mm thermal insulation, maintaining surrounding tissues below 45 °C during ablation.
  • The system induced robust immunogenic cell death, dendritic cell maturation, and high M1 macrophage polarization (95% in vitro, 35% in vivo).
  • Integrated therapy achieved complete tumor eradication in 50% of animals, sterilizing residual tumor cells.

Conclusions:

  • The developed material-driven platform enhances thermal ablation safety and efficacy.
  • Coordinated thermal modulation and programmable drug release overcome key limitations in current ablation techniques.
  • This strategy offers a translational approach for improved cancer treatment outcomes.