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Updated: Jul 13, 2025

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants
Published on: March 1, 2019
A polymer network architecture provides superior cushioning and lubrication of soft tissue compared to a linear
Benjamin G Cooper1,2, Christian D DeMoya2,3, Katie J Sikes4
1Department of Chemistry, Boston University, Boston, MA, 02215, USA. mgrin@bu.edu.
Abstract:
We report the relationships between linear vs. network polymer architecture and biomechanical outcomes including lubrication and cushioning when the polymers are applied to the surface of articulating knee cartilage. Aqueous formulations of the bioinspired polymer poly(2-methacryloyloxylethyl phosphorylcholine) (pMPC) exhibit tuneable rheological properties, with network pMPC exhibiting increased elasticity and viscosity compared to linear pMPC. Application of a polymer network, compared to a linear one, to articulating tissue surfaces reduces friction, lessens tissue strain, minimizes wear, and protects tissue - thereby improving overall tissue performance. Administration of the network pMPC to the middle carpal joint of skeletally mature horses elicits a safe response similar to saline as monitored over a 70 day period.
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