Related Experiment Video
Updated: Oct 10, 2026

Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model
Published on: March 6, 2012
[Radiation and combination therapy of malignant tumors of the vulva]
Abstract:
The paper is concerned with the results of radiation and multimodality (chemo- and radiotherapy) therapy of patients with malignant vulval tumors. All 112 patients had Stage III-IV disease. A single focal dose was 1.8-2.5 Gy, a summary dose varied from 65 to 100 Gy depending on growth type, tumor histological structure and other factors. Cyclophosphamide, thiotepa, methotrexate and 5-FU were used during simultaneous chemotherapy. Single and summary doses were administered according to an individual program. Drugs reducing local and general radiation reactions were widely used. A direct clinical cure and partial resorption were noted in 109 patients, no effect in 3. The use of various methods of gamma-beam therapy and chemoradiotherapy resulted in the 3-year survival in 51% and the 5-year survival in 18.7% of the patients.
Related Concept Videos
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Mutations
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Tumor Immunotherapy
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

