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Updated: Jul 13, 2025
The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
Published on: September 27, 2016
A PVDF-based colorimetric sensor array for noninvasive detection of multiple disease-related volatile organic
Jingzhou Hou1,2, Xiaofang Liu2, Changjun Hou1
1Postdoctoral Research Station, Chongqing University, Bioengineering College of Chongqing University, Chongqing, 400044, People's Republic of China.
Abstract:
Detection of human-generated volatile organic compounds (VOCs) is a new pathway for assessing health. Herein, a polyvinylidene fluoride (PVDF)-based colorimetric sensor array was designed for detecting disease-related VOCs (DVOCs) within 15 min, using a complex of Cu metal-organic framework, graphene aerogel, and dyes as response materials. Fingermaps derived from 28 DVOCs were obtained for further data processing. Pattern recognition was successfully employed in the correct discrimination of 28 DVOCs in low (10 μM), medium (100 μM), and high (300 μM) concentrations. Importantly, the sensor array also presented excellent discrimination ability and application potential when detecting VOCs produced by human cancer and normal cells. In general, VOC acquisition is noninvasive and harmless, and the PVDF-based sensor arrays are simple and visual. Such advantages expand their further application potential.
