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Related Experiment Video

Updated: Jul 13, 2025

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
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Polymer translocation driven by longitudinal and transversal time-dependent end-pulling forces.

A Sáinz-Agost1,2, F Falo1,2, A Fiasconaro1,2,3

  • 1Departamento de Física de la Materia Condensada, Universidad de Zaragoza, Zaragoza 50009, Spain.

Physical Review. E
|October 18, 2023
PubMed
Summary
This summary is machine-generated.

We simulated polymer translocation through a pore using end-pulled forces. A resonant activation effect was observed, showing a minimum in translocation time with frequency, independent of polymer flexibility.

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Area of Science:

  • Polymer physics
  • Soft matter physics
  • Statistical mechanics

Background:

  • Understanding polymer dynamics is crucial in nanotechnology and biophysics.
  • Simulating polymer translocation through nanopores provides insights into biological processes and synthetic applications.

Purpose of the Study:

  • To investigate the translocation of a semiflexible homopolymer through an extended pore.
  • To analyze the effects of constant and time-dependent end-pulled forces (longitudinal and transversal) on translocation dynamics.
  • To identify resonant activation effects and their dependence on force frequency and polymer properties.

Main Methods:

  • Simulations of a semiflexible homopolymer model.
  • Application of constant and cosine-function time-dependent end-pulled forces.
  • Distinction between longitudinal and transversal force application relative to the pore axis.

Main Results:

  • A significant minimum in mean translocation times was observed as a function of force frequency, indicative of resonant activation.
  • This resonant effect was independent of the polymer's elastic characteristics.
  • A linear relationship was found between optimal mean translocation time and driving period.
  • Mean translocation times exhibited different scaling exponents with polymer length for varying flexibilities.

Conclusions:

  • The study reveals a resonant activation phenomenon in polymer translocation driven by time-dependent forces.
  • Analytical expressions for low driving frequencies align well with simulation results.
  • The findings offer insights into optimizing polymer translocation processes through controlled force application.