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Updated: Jul 13, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
Published on: November 10, 2023
COVID-19? Let me see your hands.
David Bernal-Bello1, Celia Lara-Montes1, Beatriz Jaenes-Barrios2
1Department of Internal Medicine, Hospital Universitario de Fuenlabrada, Madrid, Spain.
A patient with anti-synthetase syndrome (ASS) was initially misdiagnosed with COVID-19 pneumonia. Comprehensive evaluation revealed overlooked ASS symptoms and an underlying colon malignancy, highlighting the need for vigilant screening.
Area of Science:
- Rheumatology
- Pulmonology
- Oncology
Background:
- Anti-synthetase syndrome (ASS) is a rare autoimmune disease.
- COVID-19 pandemic presented diagnostic challenges.
- ASS is considered a low-risk subgroup for cancer in idiopathic inflammatory myopathies.
Purpose of the Study:
- To highlight diagnostic challenges in patients with ASS during the COVID-19 pandemic.
- To emphasize the importance of comprehensive clinical evaluation for accurate diagnosis.
- To discuss the association between ASS and underlying malignancies.
Main Methods:
- Case report of a patient with ASS misdiagnosed as COVID-19 pneumonia.
- Review of physical examination and laboratory findings.
- Screening for underlying malignancy.
Main Results:
- The patient was initially misdiagnosed with severe acute respiratory syndrome coronavirus 2 pneumonia.
- Overlooked physical and laboratory data were consistent with ASS.
- A malignant colon lesion was discovered during cancer screening.
Conclusions:
- Comprehensive clinical evaluation is crucial for early and accurate diagnosis of ASS, even during a pandemic.
- While ASS may represent a lower cancer risk, adequate screening for malignancy remains essential.
- This case underscores the need for tailored cancer screening in patients with ASS, considering individual risk factors.
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