Related Experiment Video
Updated: Jul 13, 2025
07:54
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
19.8K
Obstructive Sleep-Disordered Breathing in Infants with Normal Awake Clinical Examination: Contribution of
Marie-Eva Rossi1, Claire Le Treut2, Laure Allali2
1Department of Pediatric Otolaryngology Head and Neck Surgery, La Timone Children's Hospital, APHM, Aix-Marseille Univ, Marseille, France. marie-eva.rossi@ap-hm.fr.
Indian Journal of Pediatrics
|October 18, 2023
Summary
Drug-induced sleep endoscopy (DISE) effectively identifies airway obstruction in infants with suspected obstructive sleep-disordered breathing. This diagnostic tool guides surgical treatment when awake examinations are inconclusive.
Area of Science:
- Pediatric Otolaryngology
- Sleep Medicine
- Diagnostic Imaging
Background:
- Obstructive sleep-disordered breathing (OSDB) in infants often lacks clear causes on clinical examination.
- Accurate diagnosis is crucial for effective treatment and preventing complications.
Purpose of the Study:
- To evaluate the utility of drug-induced sleep endoscopy (DISE) in diagnosing the cause of OSDB in infants.
- To determine if DISE can guide therapeutic interventions.
Main Methods:
- A prospective study included 32 infants with OSDB and normal awake examinations.
- All infants underwent DISE, with obstructive sites scored using the NAVOTEL system.
- Flexible laryngoscopy was performed prior to DISE.
Main Results:
- DISE identified an obstructive site in 93.8% of infants.
- Common findings included isolated sleep laryngomalacia (37.4%) and adenotonsillar hypertrophy (21.8%).
- DISE guided surgical management in 81.3% of cases.
Conclusions:
- DISE is a valuable tool for diagnosing the cause of OSDB in infants with initially unclear findings.
- DISE aids in guiding appropriate pre-therapeutic and surgical management decisions.
Related Concept Videos
01:21Sleep Apnea
164
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
164
01:29Endoscopic Procedures I: Esophagogastroduodenoscopy
131
An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
During an EGD, the endoscope can be used to:
131
01:17Sleepwalking and Sleep Talking
173
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
173
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
183
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
183
01:24Sleep-Wake Cycles
1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K
01:24Substance Use Disorders Affecting Sleep
174
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
174