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Hybrid Functional Polymer-Enabled Multiplexed Chemosensor Patch for Wearable Adrenocortex Stress Profiling.

Sanjida Yeasmin1, Ahasan Ullah1, Bo Wu1

  • 1School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, Oregon 97331, United States.

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Summary
This summary is machine-generated.

This study introduces a novel sensor for directly measuring stress hormones cortisol and dehydroepiandrosterone (DHEA) in sweat. This label-free method enables rapid, on-skin assessment of the hypothalamic-pituitary-adrenal axis function.

Keywords:
adrenocortex stress profileelectrochemical sensorexternal redox reagent-freelabel-freemolecularly imprinted polymerpoint of caresteroid hormones

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Area of Science:

  • Electrochemistry
  • Biomedical Engineering
  • Analytical Chemistry
  • Wearable Sensors

Background:

  • Accurate assessment of stress hormone levels, such as cortisol and dehydroepiandrosterone (DHEA), is crucial for understanding hypothalamic-pituitary-adrenal (HPA) axis function and physiological stress responses.
  • Conventional methods for steroid hormone detection are often time-consuming, require complex procedures, rely on unstable biological receptors, and necessitate specialized equipment, limiting their application in real-time monitoring.

Purpose of the Study:

  • To develop a novel, label-free, and reagent-free amperometric assay for the direct detection of cortisol and DHEA in sweat.
  • To create a wearable sensing system for ambulatory monitoring of stress hormone levels directly on the skin.

Main Methods:

  • Development of multitarget sensors utilizing redox-active molecularly imprinted polymers (redox MIPs) with specific binding cavities for cortisol and DHEA.
  • Incorporation of a stable electrochemical redox-active component (polyvinylferrocene) within the polymer matrix to enable sensitive current changes upon target hormone capture.
  • Integration of the developed redox MIP sensors into a wireless wearable sensing system for on-skin sweat analysis.

Main Results:

  • The multiplexed sensor achieved rapid detection (within 5 minutes) of both cortisol and DHEA with low detection limits (115 pM and 390 pM, respectively).
  • Successful ambulatory detection of cortisol and DHEA in sweat directly on the skin was demonstrated using the integrated wearable sensing system.
  • The assay provides a robust and rapid method for determining the cortisol-DHEA ratio, offering insights into the HPA axis.

Conclusions:

  • A novel amperometric sensing platform based on redox MIPs enables direct, label-free, and reagent-free detection of sweat cortisol and DHEA.
  • The developed wearable sensing system facilitates real-time, on-skin monitoring of key stress hormones, overcoming limitations of conventional methods.
  • This technology holds significant promise for point-of-care assessment of physiological stress and HPA axis status.