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Human Parechovirus Central Nervous System Infection in a Young Infant Cohort

Aspasia Katragkou1,2, Avni Sheth3, Christina Gagliardo1,2

  • 1From the Infectious Diseases Division, Department of Pediatrics, Atlantic Health System, Goryeb Children's Hospital, Morristown, New Jersey.

The Pediatric Infectious Disease Journal
|October 18, 2023
PubMed

Insights

A 2022 surge of pediatric human parechovirus (HPeV) central nervous system infections in infants showed similar clinical features. This highlights the need for better treatment evaluation and standardized follow-up for long-term prognosis.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Neurology

Background:

  • Human parechovirus (HPeV) infections can cause severe central nervous system (CNS) disease in infants.
  • A notable increase in pediatric HPeV CNS infections occurred in 2022 at our institution.

Purpose of the Study:

  • To describe the clinical features of HPeV CNS infections during a 2022 surge.
  • To emphasize the need for improved treatment strategies and long-term outcome assessment for affected infants.

Main Methods:

  • Retrospective case review of infants diagnosed with HPeV CNS infections.
  • Clinical data analysis including symptoms, severity, and outcomes.

Main Results:

  • The 2022 surge involved a significant increase in HPeV CNS infection cases.
  • Clinical presentations remained consistent with previous years despite the surge.
  • No new or unusual clinical manifestations were identified during the surge.

Conclusions:

  • The clinical course of HPeV CNS infections in infants did not change during the 2022 surge.
  • Further research into treatment efficacy and standardized follow-up protocols is crucial.
  • Understanding long-term prognosis for infants with HPeV infection requires ongoing investigation.

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