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The Cohort of Indonesian Preterm Infants for Long-term Outcomes (CIPTO) study: a protocol
Rinawati Rohsiswatmo1, Hardya Gustada Hikmahrachim2, Muhamad Azharry Rully Sjahrulla2
1Division of Perinatology, Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. rinarohsis@gmail.com.
Insights
Indonesia faces a high burden of preterm births, necessitating local evidence for infant care. This study tracks ex-preterm infants to establish long-term growth and development references for improved outcomes.
Area of Science:
- Neonatal Medicine
- Pediatric Development
- Public Health
Background:
- Indonesia experiences approximately 600,000 preterm births annually, straining healthcare resources.
- There is a critical need for Indonesia-specific, evidence-based guidelines for managing premature and ex-preterm infants.
- Existing long-term studies on preterm infants in Indonesia are lacking.
Purpose of the Study:
- To evaluate the long-term growth and development of ex-preterm infants in Indonesia until the pre-pubertal stage.
- To establish an evidence-based reference for preterm infant care tailored to the Indonesian context.
- To determine optimal outcomes for premature neonates and survivors.
Main Methods:
- A prospective cohort study, the Cohort of Indonesian Preterm Infants for Long-term Outcomes (CIPTO), was designed.
- Recruitment of at least 500 preterm infants at Cipto Mangunkusumo General Hospital (CMGH) over two years.
- Long-term follow-up of ex-preterm infants until 8 years old, assessing survival, growth, neurodevelopment, feeding, and sensory impairments.
Main Results:
- This section is not yet available as the study is ongoing.
- The study aims to collect comprehensive data on growth and neurodevelopmental milestones up to 8 years of corrected age.
- Data collection points include multiple assessments during infancy and annually from age 3 to 8.
Conclusions:
- The CIPTO study is the first prospective cohort in Indonesia focusing on preterm infants.
- Findings will provide crucial insights for developing Indonesia's healthcare reference for preterm infant management.
- The study aims to ensure optimal long-term outcomes for ex-preterm infants in Indonesia.
Background:
Indonesia has high numbers of preterm birth, i.e., around 600,000 preterm births annually. It imposes a significant burden on the Indonesia's healthcare system. Indonesia therefore requires its own evidence-based reference to manage premature neonates and ex-preterm infants who subsequently survived. No long-term study on preterm infants in Indonesia has been conducted, therefore we aim to evaluate growth and development on ex-preterm infants until the pre-pubertal stage.
Methods:
We at the Cipto Mangunkusumo General Hospital (CMGH) designed a prospective cohort study of preterm infants, i.e., the Cohort of Indonesian Preterm Infants for Long-term Outcomes (CIPTO) study. At least 500 subjects will be recruited with an estimation of two-year recruitment (i.e., the recruitment phase will be completed before 2024). The CIPTO study will observe long-term outcomes of ex-preterm infants, primarily on growth and developmental milestones until 8 years old. Aims of this study are to determine the ex-preterm outcomes and to generate an evidence-based reference of preterm care for ensuring optimum outcomes. The pre-specified long-term outcomes in this study are survival rates, growth outcomes, neurodevelopmental outcomes, feeding behavior, as well as hearing and vision impairments. Growth and neurodevelopmental outcomes will be assessed at 0, 2, 4, 6, 9, 12, 15, 18 and 24 months of corrected age as well as at 3, 4, 5, 6, 7 and 8 years old.
Discussion:
The CIPTO study is the first prospective cohort in Indonesia focusing on preterm infants born at the CMGH. With a follow up until 8 years old, this study may provide useful insights to generate an evidence-based, Indonesia's health care reference in managing premature infants and ensuring the optimum outcomes of ex-preterm infants.
