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Serum lactate dehydrogenase level in various malignancies
Neoplasma
|January 1, 1986
Summary
Serum lactate dehydrogenase (SLD) levels are significantly elevated in cancer patients compared to healthy individuals, suggesting a link between enzymatic activity and cancer. Postoperative SLD levels in breast cancer patients indicate therapy effectiveness.
Area of Science:
- Biochemistry
- Oncology
- Clinical Chemistry
Background:
- Serum lactate dehydrogenase (SLD) is an enzyme present in various tissues.
- Elevated SLD levels have been anecdotally linked to neoplastic conditions.
Purpose of the Study:
- To investigate the association between serum lactate dehydrogenase (SLD) enzymatic activity and cancer.
- To determine if SLD levels can serve as a diagnostic or prognostic marker for cancer.
Main Methods:
- Serum samples were collected from 205 normal individuals, 201 cancer patients, and 202 patients with nonmalignant diseases.
- Total serum lactate dehydrogenase (SLD) levels were measured and statistically analyzed.
- A postoperative follow-up study was conducted on breast cancer patients.
Main Results:
- Cancer patients exhibited significantly higher preoperative SLD levels (314.56 U/l) compared to normal (105.50 U/l) and nonmalignant disease patients (105.87 U/l).
- No significant bisexual differences in SLD levels were observed.
- Postoperative SLD levels in breast cancer patients showed decreased enzymatic activity, correlating with therapy effectiveness.
Conclusions:
- Elevated SLD levels in cancer patients suggest the release of lactate dehydrogenase by neoplastic cells.
- SLD activity is a valuable indicator for cancer diagnosis, prognosis, and monitoring therapy effectiveness, particularly in breast cancer.