Related Experiment Video
Updated: Jul 12, 2025
Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
Published on: July 5, 2024
Host modulation therapy for improving the osseointegration of dental implants under bone healing-suppressed
Young Woo Song1,2, Jin-Young Park2,3, Yoon-Hee Kwon2,3
1Department of Periodontology, Gangnam Severance Hospital, Yonsei University College of Dentistry, Seoul, Korea.
Purpose:
Placing dental implants in areas with low bone density or in conditions where bone healing is suppressed is challenging for clinicians. An experiment using a rodent model was performed with the aim of determining the efficacy of host modulation by increasing the systemic level of cholesterol sulfate (CS) using Irosustat in the context of the bone healing process around dental implants.
Methods:
In 16 ovariectomised female Sprague-Dawley rats, 2 implant fixtures were placed in the tibial bones (1 fixture on each side). At 1 week after surgery, the high-CS group (n=8) received Irosustat-mixed feed, while the control group (n=8) was fed conventionally. Block specimens were obtained at 5 weeks post-surgery for histologic analysis and the data were evaluated statistically (P<0.05).
Results:
Unlike the high-CS group, half of the specimens in the control group demonstrated severe bone resorption along with a periosteal reaction in the cortex. The mean percentages of bone-to-implant contact (21.5%) and bone density (28.1%) near the implant surface were significantly higher in the high-CS group than in the control group (P<0.05), as was the number of Haversian canals (by 5.3).
Conclusions:
Host modulation by increasing the CS level may enhance the osseointegration of dental implants placed under conditions of impaired bone healing.
