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Application of microfluidic technologies in forensic analysis.

Yuxin Guo1,2, Xingru Zhang1,2,3,4, Haoqing Zhang5,6

  • 1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China.

Electrophoresis
|October 19, 2023
PubMed
Summary

Microfluidic technology offers cost-effective, rapid, and efficient solutions for forensic medicine. This review evaluates its use in forensic genetics, highlighting current applications and future directions.

Keywords:
forensic geneticsforensic medicinemicrofluidicµTAS

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Area of Science:

  • Forensic Science
  • Biotechnology
  • Analytical Chemistry

Background:

  • Microfluidic technology has gained prominence in forensic medicine over the past two decades.
  • Its advantages include low cost, speed, high throughput, user-friendliness, and minimal sample/reagent use.
  • This technology minimizes contamination risks in forensic analyses.

Purpose of the Study:

  • To provide an impartial evaluation of microfluidic technology's utilization in forensic medicine.
  • To analyze the co-occurrence of forensic and microfluidic topics in scientific literature.
  • To elaborate on microfluidic applications, especially within forensic genetics.

Main Methods:

  • Bibliometric analysis of literature from Science Citation Index Expanded (1989-2022).
  • Co-occurrence analysis of keywords related to forensic science and microfluidics.
  • In-depth interpretation of literature based on co-occurrence findings.

Main Results:

  • Identification of key research trends and collaborations in microfluidics for forensic applications.
  • Elaboration of specific microfluidic techniques applied in forensic genetics, such as DNA extraction and analysis.
  • Mapping the evolution of microfluidic technology adoption in the forensic field.

Conclusions:

  • Microfluidic technology presents significant potential for advancing forensic medicine, particularly in genetics.
  • Challenges remain in widespread implementation and standardization.
  • Future trends point towards integrated microfluidic systems for comprehensive forensic analysis.