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Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension.

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Post-stroke immunosuppression: Exploring potential implications beyond infections.

David Brea1,2

  • 1Department of Neuroscience and Experimental Therapeutics, Instituto de Investigaciones Biomédicas de Barcelona (IIBB), Consejo Superior de Investigaciones Científcas (CSIC), Barcelona, Spain.

The European Journal of Neuroscience
|October 19, 2023
PubMed
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Stroke triggers a profound immunosuppression, increasing infection risk and disrupting organ function. This review details post-stroke immune system impacts on organs like the spleen, bone marrow, and heart.

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Area of Science:

  • Neuroscience
  • Immunology
  • Pathophysiology

Background:

  • Stroke is a primary cause of death and disability, characterized by disrupted cerebral blood flow.
  • The immune response is crucial in stroke, but its impact on overall immune physiology is understudied.
  • Post-stroke, a shift from inflammation to significant immunosuppression occurs within hours to days.

Conclusions:

  • Post-stroke immunosuppression has widespread consequences beyond the brain.
  • Understanding these effects is critical for managing stroke patient health and preventing complications.
  • Further research into immune organ function post-stroke is warranted.