Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measure What Matters: Rethinking Surrogate Metrics of Success in Radiation Oncology.

International journal of radiation oncology, biology, physics·2026
Same author

Automated Analysis of Radiation Oncology Incident Reports Using Large Language Models: A Multi-Institutional Technical Validation Study.

International journal of radiation oncology, biology, physics·2026
Same author

A Dosimetric Comparison of the Accumulated Dose in Prostate SBRT for Non-Adaptive and Adaptive External Beam Radiotherapy.

Cancers·2026
Same author

An AI-assisted, failure mode-based toolkit for proactive risk management in radiotherapy: A feasibility study.

Technical innovations & patient support in radiation oncology·2026
Same author

Artificial intelligence in radiation therapy: from imaging to delivery-a comprehensive review.

BJR artificial intelligence·2026
Same author

A surface-conforming flexible collimator for improving electron radiotherapy.

Physics in medicine and biology·2026

Related Experiment Video

Updated: Jul 12, 2025

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

11.9K

Dosimetric characterization of a new surface-conforming electron MLC prototype.

Holly M Parenica Paschal1, Christopher N Kabat1, Thomas Martin1

  • 1Department of Radiation Oncology, School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

Journal of Applied Clinical Medical Physics
|October 20, 2023
PubMed
Summary

A novel surface-conforming electron multileaf collimator (SCEM) was developed to reduce radiation toxicity. The SCEM improves penumbra and out-of-field dose but increases surface dose, requiring further optimization.

Keywords:
electron therapymulti-leaf collimatorskin collimation

More Related Videos

Comprehensive Characterization of Extended Defects in Semiconductor Materials by a Scanning Electron Microscope
11:14

Comprehensive Characterization of Extended Defects in Semiconductor Materials by a Scanning Electron Microscope

Published on: May 28, 2016

13.9K
Using Laser Scanning Microscopy to Determine Electromigration in Molybdenum Disilicide
09:44

Using Laser Scanning Microscopy to Determine Electromigration in Molybdenum Disilicide

Published on: May 23, 2025

108

Related Experiment Videos

Last Updated: Jul 12, 2025

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

11.9K
Comprehensive Characterization of Extended Defects in Semiconductor Materials by a Scanning Electron Microscope
11:14

Comprehensive Characterization of Extended Defects in Semiconductor Materials by a Scanning Electron Microscope

Published on: May 28, 2016

13.9K
Using Laser Scanning Microscopy to Determine Electromigration in Molybdenum Disilicide
09:44

Using Laser Scanning Microscopy to Determine Electromigration in Molybdenum Disilicide

Published on: May 23, 2025

108

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Radiotherapy Equipment Development

Background:

  • Electron therapy in radiation oncology aims to minimize normal tissue toxicity.
  • Conventional collimation methods like Cerrobend cutouts have limitations in dose conformity and out-of-field dose reduction.
  • The development of advanced collimation techniques is crucial for improving treatment efficacy and patient safety.

Purpose of the Study:

  • To introduce and evaluate a surface-conforming electron multileaf collimator (SCEM) for electron therapy.
  • To assess the SCEM's ability to reduce normal tissue radiation toxicity.
  • To compare the SCEM's dosimetric properties against traditional Cerrobend cutouts.

Main Methods:

  • Construction of an early prototype of the SCEM with acrylic leaves designed to conform to patient surfaces.
  • Dosimetric measurements using water tank scans for various electron energies (6-15 MeV) and field sizes at a 100 cm source-to-surface distance (SSD).
  • Comparison of SCEM measurements with Cerrobend cutouts at matched field sizes and 100/110 cm SSD, including output factor and percent depth dose (PDD) analysis.

Main Results:

  • The SCEM demonstrated a significant decrease in penumbra, especially at lower energies (6-9 MeV), compared to Cerrobend cutouts at 110 cm SSD.
  • Reduced out-of-field dose and lower bremsstrahlung production were observed with the SCEM.
  • Percent depth dose (PDD) curves shifted shallower with the SCEM, and a higher surface dose was noted (up to 9.8% increase).

Conclusions:

  • The SCEM offers significant improvements in penumbra and out-of-field dose reduction compared to Cerrobend cutouts by enabling close-to-surface collimation.
  • Increased shallow PDD values due to added scatter from the SCEM require further investigation and mitigation.
  • Future research will focus on optimizing the SCEM design to minimize scatter while preserving its dosimetric advantages.