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Updated: Jul 12, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Transforming health and well-being through publishing computable biomedical knowledge (CBK)
Güneş Koru1,2
1Department of Health Policy and Management University of Arkansas for Medical Sciences (UAMS) Fayetteville Arkansas USA.
Computable biomedical knowledge artifacts (CBKs), software transforming data, are crucial for learning health systems. A new peer-review track in the Learning Health Systems journal aims to improve CBK verification, documentation, and adoption.
Area of Science:
- Biomedical Informatics
- Health Systems Science
- Software Engineering
Background:
- Computable biomedical knowledge artifacts (CBKs) are software tools vital for advancing learning health systems.
- Widespread adoption of CBKs is hindered by challenges in verification, documentation, and dissemination.
- The Learning Health Systems journal established a dedicated track for publishing CBKs to address these limitations.
Purpose of the Study:
- To introduce and evaluate a new peer-review track for CBKs within the Learning Health Systems journal.
- To foster the development, verification, and dissemination of high-quality CBKs.
- To encourage broader engagement with CBKs in biomedical research and learning health systems.
Main Methods:
- A new peer-review track was established in the Learning Health Systems journal for publishing CBKs.
- Manuscripts included reports of functioning CBKs and discussions on methodological, policy, deployment, and platform issues.
- The track facilitates a structured approach to the validation and publication of CBKs.
Main Results:
- The special issue features eight manuscripts, with four presenting functional CBKs and four addressing ecosystem-related challenges.
- The peer-review process aims to enhance the reproducibility, reusability, and trustworthiness of biomedical software.
- This initiative highlights the potential of CBKs to drive innovation in learning health systems.
Conclusions:
- The CBK track provides a vital channel for the peer-reviewed publication of computable biomedical knowledge artifacts.
- Improved verification and dissemination through this track are expected to accelerate the integration of CBKs into learning health systems.
- This effort encourages scientists to embrace CBKs as a new form of scientific discourse and tool for advancing healthcare.
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