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Related Concept Videos

Electron Transport Chain: Complex I and II01:46

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Related Experiment Video

Updated: Jul 12, 2025

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
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A mitochondrial checkpoint to adaptive anticancer immunity.

Oliver Kepp1,2,3, Peng Liu1,2, Guido Kroemer1,2,4

  • 1Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris, France.

Oncoimmunology
|October 20, 2023
PubMed
Summary
This summary is machine-generated.

The BCL2 protein preserves mitochondrial integrity, inhibiting innate immunity and apoptosis. New data show BCL2 also suppresses adaptive immunity by dendritic cells, suggesting a broad immunosuppressive role.

Keywords:
Antigen presentationCGASimmune checkpoint inhibitorsimmunogenic cell deathmtDNAtype I interferon

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • BCL2 protein is known to maintain mitochondrial integrity.
  • It also inhibits innate immune signaling and programmed cell death (apoptosis).

Purpose of the Study:

  • To investigate the role of BCL2 in adaptive immune responses.
  • To determine if BCL2 has a broader immunosuppressive function.

Main Methods:

  • Analysis of recent experimental data.
  • Focus on the function of dendritic cells in adaptive immunity.

Main Results:

  • BCL2 limits the capacity of dendritic cells to initiate adaptive immune responses.
  • This finding extends the known functions of BCL2 beyond innate immunity.

Conclusions:

  • BCL2 exhibits a universal immunosuppressive function.
  • It acts as a mitochondrial immune checkpoint, regulating both innate and adaptive immunity.