Related Experiment Video

Updated: Jul 12, 2025

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

6.6K

Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity

Morgan Brisset1,2,3, Patrick Mehlen3, Olivier Meurette3

  • 1Department of Clinical Pathology, Victorian Comprehensive Cancer Centre, The University of Melbourne, Melbourne, VIC, Australia.

Frontiers in Cell and Developmental Biology
|October 20, 2023
PubMed

Insights

Notch signaling heterogeneity drives cancer stem cell (CSC) diversity in colorectal cancer (CRC), impacting treatment resistance and recurrence. Understanding ligand-receptor interactions is key to targeting these cells for better patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Cancer cell heterogeneity contributes to therapeutic failure and recurrence.
  • Targeting chemoresistant cancer stem cells (CSCs) is a promising therapeutic strategy.
  • Notch signaling regulates CSC features in colorectal cancer (CRC).

Purpose of the Study:

  • To review how Notch signaling heterogeneity influences CSC stemness, self-renewal, and chemoresistance in CRC.
  • To explore the role of Notch ligand-receptor specificity in CRC cell heterogeneity.

Main Methods:

  • Literature review focusing on Notch signaling pathways in colorectal cancer.
  • Analysis of studies investigating cancer stem cell characteristics.
  • Synthesis of current understanding of Notch signaling in CRC heterogeneity.

Main Results:

  • Notch signaling is a critical regulator of stemness, self-renewal, and chemoresistance in CRC.
  • Heterogeneity in Notch signaling contributes to the diversity of CSC subpopulations.
  • Specific Notch ligand-receptor interactions play a role in modulating CSC behavior.

Conclusions:

  • Notch signaling heterogeneity is a significant factor in colorectal cancer stem cell biology.
  • Targeting specific Notch pathways may offer new strategies to overcome chemoresistance and recurrence.
  • Further research into Notch ligand-receptor specificity is needed to develop effective therapies.
Keywords:
chemoresistancecolorectal neoplasmsneoplastic stem cellsposttreatment recurrenceself-renewaltumor hetereogeneity

More Related Videos

In vitro Organoid Culture of Primary Mouse Colon Tumors07:33

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

35.1K
A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells06:38

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

Published on: January 22, 2021

6.1K

Related Concept Videos

Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.1K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.0K