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Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

281
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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Parkinson's Disease: Overview01:15

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Active and Passive Cycling Decrease Subthalamic β Oscillations in Parkinson's Disease.

Vasiliki Bougou1,2, Michaël Vanhoyland1,2,3, Thomas Decramer1,2,3

  • 1Research Group of Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, KU Leuven and the Leuven Brain Institute, Leuven, Belgium.

Movement Disorders : Official Journal of the Movement Disorder Society
|October 20, 2023
PubMed
Summary
This summary is machine-generated.

Cycling, particularly passive cycling, strongly suppresses beta oscillations in Parkinson's disease patients. This beta suppression is more pronounced in those with freezing of gait, suggesting therapeutic potential for rhythmic mobilization.

Keywords:
electrophysiologymovement disorderssubthalamic nucleus

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Area of Science:

  • Neuroscience
  • Movement Disorders
  • Biomedical Engineering

Background:

  • Parkinson's disease (PD) impacts motor control, with freezing of gait (FOG) being a debilitating symptom.
  • Understanding preserved motor capabilities like cycling in PD is crucial for developing effective therapies.
  • Previous studies suggest cycling enhances motor continuation by suppressing beta oscillations in the subthalamic nucleus (STN).

Purpose of the Study:

  • To investigate the effects of active and passive cycling on neural activity in the STN of PD patients.
  • To compare these effects between patients with and without FOG.
  • To determine the role of sensory input during cycling in modulating brain activity.

Main Methods:

  • Local field potentials (LFPs) were recorded from the STN in 12 PD patients (6 with FOG, 6 without FOG).
  • Beta (13-30 Hz) and high gamma (60-100 Hz) power were analyzed during active and passive cycling at various cadences.
  • Passive cycling utilized a motor-driven setup to isolate sensory input effects.

Main Results:

  • Both active and passive cycling significantly suppressed pathological beta activity.
  • Active cycling showed increased high gamma band activity compared to passive cycling.
  • Beta suppression was more pronounced in patients with FOG, particularly during passive cycling.
  • Cadence did not influence the observed effects of cycling on neural activity.

Conclusions:

  • Proprioceptive input during cycling is linked to beta-wave suppression in PD.
  • Continuous external sensory input and proprioceptive feedback from rhythmic cycling facilitate motor control.
  • Systematic passive mobilization through cycling may offer therapeutic benefits for PD patients, especially those with FOG.