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Updated: Jul 12, 2025

Monitoring the Effect of Osmotic Stress on Secretory Vesicles and Exocytosis
Published on: February 19, 2018
How micron-sized exocrine vesicles release content: A comparison with sub-micron endocrine vesicles
Lisi Wei1, Xin Wang1, Ling-Gang Wu1
1National Institute of Neurological Disorders and Stroke , Bethesda, MD, USA.
Abstract:
Exocytosis releases vesicular contents to mediate physiological functions. In this issue, Biton et al. (https://doi.org/10.1083/jcb.202302112) found four modes of releasing micron-sized exocrine vesicles and the underlying mechanisms involving actomyosin and BAR domain proteins. We highlight their discovery, compare it with much smaller/faster neuroendocrine vesicle fusion, and draw distinct and conserved principles regarding their membrane transformations, pore dynamics, and underlying mechanisms.
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