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Updated: Jul 12, 2025
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Published on: February 16, 2015
Tumor-reactive T helper cells in the context of vaccination against glioma
Binghao Zhao1, Michael Kilian1, Theresa Bunse1
1CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neuroscience, Heidelberg University, Mannheim, Germany; German Cancer Consortium (DKTK), DKFZ, core center, Heidelberg, Germany.
Abstract:
With the advances in immunogenomics, the majority of tumor-specific antigens were found to be recognized by T helper cells (THCs). This observation led to the development of long epitope vaccines in various cancers. Mechanistically, we are still gaining a deeper understanding of the mode of action of THCs as precision antitumor agonists. Here, we discuss the specific cellular mechanisms of THC functions in glioma immunology and contextualize current advances in anti-glioma vaccination exploiting THCs.
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