A malignant peripheral nerve-sheath tumor: A CARE case report

Area of Science:

• Oncology
• Surgical Pathology

Background:

• Malignant peripheral nerve-sheath tumor (MPNST) is an exceptionally rare sarcoma affecting the nasal cavity and paranasal sinuses.
• Its non-specific presentation and diagnostic challenges contribute to limited physician awareness.

Observation:

• A 62-year-old woman presented with progressive right cheek and hard palate swelling.
• Imaging revealed a maxillary sinus mass with significant osteolysis of surrounding structures.
• Histopathological analysis confirmed a low-grade MPNST.

Findings:

• Complete surgical resection of the maxillary sinus MPNST was achieved.
• Adjuvant radiotherapy (60Gy) was administered post-operatively.
• A 2-year follow-up demonstrated no evidence of tumor recurrence.

Implications:

• MPNST of the sinonasal region requires prompt diagnosis and aggressive management.
• Wide surgical resection is crucial due to the high risk of recurrence.
• Adjuvant radiotherapy should be considered, especially when complete resection is challenging due to anatomical proximity to critical structures.