Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

456
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
456
Cancer Prevention02:59

Cancer Prevention

6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.2K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

256
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
256
Pedigree Analysis01:35

Pedigree Analysis

84.4K
Overview
84.4K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

61
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
61
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Reporting Guideline for Observational Studies in Metabolomic Epidemiology: Explanation and Elaboration of the Strobe-MetEpi Checklist.

Research square·2026
Same author

Single cell transcriptome signatures and cell-cell interactions associated with sarcoidosis in lung immune cell populations.

Frontiers in immunology·2026
Same author

Real-world evidence on hospitalization, infection, and vascular outcomes among interstitial lung disease subtypes.

Respiratory medicine and research·2026
Same author

8-azido-3,8-dideoxy-D-manno-octulosonic acid-mediated metabolic oligosaccharide engineering for specific labeling of diverse <i>Enterobacterales</i>.

iScience·2026
Same author

Demographic and Physiological Differences Between Fibrotic and Nonfibrotic CT Subtypes of Sarcoidosis.

Chest·2026
Same author

Spatial transcriptomics uncovers hybrid, proinflammatory, and profibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosis.

American journal of respiratory and critical care medicine·2026

Related Experiment Video

Updated: Jul 12, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

476

Genetic predisposition to sarcoidosis.

Shu-Yi Liao1, Tasha Fingerlin2, Lisa Maier1

  • 1National Jewish Health, Department of Medicine, Denver, CO, USA; University of Colorado Anschutz Medical Campus, Department of Medicine, Aurora, CO, USA; Colorado School of Public Health, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.

Journal of Autoimmunity
|October 21, 2023
PubMed
Summary

Genetic and environmental factors influence sarcoidosis. This review examines genetic variants, ancestry, sex, and gene-environment interactions, highlighting the need for diverse populations in future sarcoidosis research.

Keywords:
GWASSarcoidosisTranscriptomics

More Related Videos

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.2K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.2K

Related Experiment Videos

Last Updated: Jul 12, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

476
Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.2K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.2K

Area of Science:

  • Genetics
  • Immunology
  • Systemic Diseases

Background:

  • Sarcoidosis is a complex systemic disease with unknown etiology.
  • Genetic predisposition and environmental exposures are implicated in its pathogenesis.
  • Clinical heterogeneity exists based on phenotypes and natural history.

Purpose of the Study:

  • To comprehensively review germline genetic (DNA) and transcriptomic (RNA) studies of sarcoidosis.
  • To assess genetic variants associated with sarcoidosis susceptibility and phenotypes.
  • To explore ancestry- and sex-specific genetic factors, shared genetic architecture with other diseases, and gene-environment interactions.

Main Methods:

  • Comprehensive literature review of germline genetic and transcriptomic studies in sarcoidosis.
  • Analysis of findings related to genetic variants, phenotypes, ancestry, sex, and gene-environment interactions.
  • Identification of unmet needs in current sarcoidosis genetic research.

Main Results:

  • Genetic variants play a significant role in sarcoidosis susceptibility and phenotypic expression.
  • Ancestry and sex-specific genetic factors influence disease presentation.
  • Shared genetic architecture exists between sarcoidosis and other diseases.
  • Gene-environment interactions are crucial in sarcoidosis pathogenesis.

Conclusions:

  • Genetic studies have elucidated key factors in sarcoidosis development.
  • Diverse populations and consistent phenotype definitions are critical for future research.
  • Advancing genetic research will improve understanding of sarcoidosis risk and manifestations.