Predictions of thumb, hand, and arm muscle parameters derived using force measurements of varying complexity and...

Subject-specific musculoskeletal models are a promising avenue for personalized healthcare. However, current methods for producing personalized models require dense, biomechanical datasets that include expensive and time-consuming physiological measurements. For personalized models to be clinically useful, we must be able to rapidly generate models from simple, easy to collect data. In this context, the objective of this paper is to evaluate if and how simple data, namely height/weight and pinch force data, can be used to achieve model personalization via machine learning. Using simulated lateral pinch force measurements from a synthetic population of 40,000 randomly generated subjects, we train neural networks to estimate four Hill-type muscle model parameters and bone density. We compare parameter estimates to the true parameters of 10,000 additional synthetic subjects. We also generate new personalized models using the parameter estimates and perform new lateral pinch simulations to compare predicted forces using these personalized models to those generated using a baseline model. We demonstrate that increasing force measurement complexity reduces the root-mean-square error in the majority of parameter estimates. Additionally, musculoskeletal models using neural network-based parameter estimates provide up to an 80% reduction in absolute error in simulated forces when compared to a generic model. Thus, easily obtained force measurements may be suitable for personalizing models of the thumb, although extending the method to more tasks and models involving other joints likely requires additional measurements.