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Optic atrophy in prematurity: pathophysiology and clinical features

Daniel Ar Scott1, Michael Tm Wang1, Helen V Danesh-Meyer1

  • 1Department of Ophthalmology, University of Auckland, Auckland, New Zealand.

Clinical & Experimental Optometry
|October 22, 2023
PubMed

Insights

Prematurity is an increasing cause of pediatric optic atrophy, leading to vision impairment. Healthcare providers should consider premature birth history in evaluations.

Area of Science:

  • Ophthalmology
  • Pediatrics
  • Neonatology

Background:

  • Optic atrophy is a significant cause of childhood visual impairment.
  • The causes of optic atrophy have evolved, with technological advancements aiding understanding.
  • Recent trends show a rise in prematurity-related optic atrophy.

Purpose of the Study:

  • To highlight the increasing role of prematurity in pediatric optic atrophy.
  • To underscore the need for better research methodologies in this field.

Main Methods:

  • Review of existing literature on pediatric optic atrophy.
  • Analysis of trends in etiological profiles over time.
  • Identification of limitations in current research.

Main Results:

  • An increasing prevalence of optic atrophy linked to prematurity has been observed.
  • This trend correlates with increased rates of premature births and improved neonatal survival.
  • Current studies are limited by sample size, heterogeneity, and bias.

Conclusions:

  • Prematurity is a growing concern in pediatric optic atrophy.
  • Larger, well-designed studies are needed to confirm this association.
  • Screening for premature birth history is crucial in evaluating children with optic atrophy.

Keywords:
Optic atrophyoptic nerve headprematuritywhite matter damage of immaturity

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