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Predictor factors for recurrence in atypical meningiomas
Andrei Ionuţ Cucu1, Claudia Florida Costea, Şerban Turliuc
1Department of Psychiatry, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania; Socola Institute of Psychiatry, Iaşi, Romania; serban_turliuc@yahoo.com; Department of Oral and Dental Diagnostics, Faculty of Dental Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania; georgiana.macovei@umfiasi.ro.
Atypical meningiomas (WHO grade 2) often recur. Tumor location, volume, resection extent, and dural sinus invasion predict recurrence and impact progression-free survival (PFS).
Area of Science:
- Neuro-oncology
- Pathology
- Neurosurgery
Background:
- Atypical meningiomas (AMs), World Health Organization (WHO) grade 2, exhibit unpredictable clinical behavior.
- Understanding recurrence predictors is crucial for managing these tumors.
Purpose of the Study:
- To identify predictors of tumor recurrence in atypical meningiomas.
- To determine factors influencing progression-free survival (PFS).
Main Methods:
- Retrospective analysis of 81 patients diagnosed with atypical meningiomas.
- Histopathological review based on WHO 2021 criteria.
- Evaluation of clinical, imaging, pathological, and surgical factors.
Main Results:
- Tumor recurrence observed in 53.1% of cases within 60 months.
- Predictive factors for recurrence included tumor location, volume, extent of resection, and dural sinus invasion.
- Gross total resection (Simpson grade I-II) achieved in 59.2% of patients.
Conclusions:
- Posterior fossa location, larger tumor volume (≥26.4 cm³), subtotal resection (Simpson grade III-IV), and dural sinus invasion are associated with relapse and shorter PFS.
- Current prognostic factors are valuable, but molecular characterization is needed for improved clinical decision-making.
