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Relationship between BDNF and oxytocin.

Donatella Marazziti1,2, Stefano Baroni1, Federico Mucci1

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Summary

This study found a significant negative correlation between oxytocin (OT) levels and platelet-derived brain-derived neurotrophic factor (PLT-BDNF) in healthy humans. These findings suggest a potential reciprocal influence between OT and BDNF in regulating physiological functions.

Keywords:
BiomarkersBrain-derived neurotrophic factorHumans plasmaInteractionsOxytocinPlatelets

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Psychoneuroimmunology

Background:

  • Brain-derived neurotrophic factor (BDNF) and oxytocin (OT) are known to interact, primarily based on animal studies.
  • Human data on the interaction between BDNF and OT is limited and indirect.
  • Peripheral markers offer a potential avenue to explore this relationship in humans.

Purpose of the Study:

  • To investigate the potential link between oxytocin (OT) and brain-derived neurotrophic factor (BDNF) in humans.
  • To examine the correlation between peripheral OT levels and two BDNF markers: platelet-poor-plasmatic-BDNF (PPP-BDNF) and platelet BDNF (PLT-BDNF).

Main Methods:

  • Study included 26 healthy young adults (both sexes).
  • Peripheral venous blood was collected for analysis of BDNF and OT levels.
  • Statistical analyses included Student's t-test, Wilcoxon-Mann-Whitney test, Pearson's correlation, and Spearman's rank correlation.

Main Results:

  • Oxytocin (OT) levels were significantly higher in women than in men.
  • A statistically significant and negative correlation was found between OT levels and platelet BDNF (PLT-BDNF) (R = -0.543, p = 0.004).
  • No significant correlation was observed between OT and PPP-BDNF.

Conclusions:

  • A significant negative correlation exists between oxytocin and platelet-derived BDNF in healthy humans.
  • Peripheral biomarkers suggest a reciprocal influence between OT and BDNF.
  • This interaction may play a role in the homeostatic regulation of stress and immune systems.