Related Experiment Video
Updated: Jul 12, 2025
14:04
Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
Published on: March 25, 2016
15.3K
Nivolumab-Induced Isolated Neutropenia
Aimal Waqas1, Javariya Zaffar2, Ahmad Jalil3
1Internal Medicine, Foundation University Medical College, Islamabad, PAK.
Cureus
|October 23, 2023
Summary
Immune checkpoint inhibitors (ICIs) can cause rare but severe neutropenia. This case highlights the importance of monitoring for hematologic adverse effects, even in asymptomatic patients, during ICI therapy for cancer.
Area of Science:
- Oncology
- Immunology
- Hematology
Background:
- Immune checkpoint inhibitors (ICIs) are revolutionary cancer therapies.
- ICIs can induce immune-related adverse events (irAEs) affecting various organ systems.
- Hematologic irAEs are rare but potentially severe complications of ICI treatment.
Observation:
- This report details a rare case of Grade 4 neutropenia.
- The neutropenia was a result of nivolumab (anti-PD-1 antibody) therapy.
- The patient had invasive bladder cancer.
Findings:
- Isolated neutropenia is a grave and rare manifestation of ICI-induced autoimmunity.
- Asymptomatic neutropenia requires vigilant monitoring.
- Severe neutropenia with fever necessitates immediate hospitalization and treatment.
Implications:
- Prompt recognition and management of ICI-induced neutropenia are crucial.
- Steroids and supportive care can effectively treat nivolumab-induced neutropenia.
- This case underscores the need for awareness of hematologic toxicities in patients receiving ICIs.
Related Concept Videos
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
170
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
170
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
217
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
217
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
305
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
305
01:25Immune Surveillance by NK Cells and Phagocytes
1.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.4K
01:25Immunodeficiency Diseases
957
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
957
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K