Causal association between adiposity and hemorrhoids: a Mendelian randomization study.

Area of Science:

• Genetics
• Epidemiology
• Metabolic Health

Background:

• Hemorrhoids are a prevalent anorectal condition globally.
• The relationship between adiposity and hemorrhoids requires further causal investigation.

Purpose of the Study:

• To investigate the causal impact of four adiposity indicators on hemorrhoid development.
• Utilizing Mendelian randomization (MR) to assess genetic predispositions.

Main Methods:

• Employed summary statistics from large-scale genome-wide association studies (GWAS) of European ancestry.
• Performed univariable and multivariable Mendelian randomization (MR) analyses.
• Utilized the MR Steiger directionality test to ascertain causal pathways.

Main Results:

• Genetically predicted higher body mass index (BMI), body fat percentage, waist circumference, and waist-to-hip ratio were associated with increased odds of hemorrhoids.
• Findings remained consistent in multivariable MR analyses, adjusting for physical activity.
• The MR Steiger test supported a causal link from adiposity to hemorrhoids, ruling out reverse causation.

Conclusions:

• This MR study provides evidence for a causal role of adiposity in the pathogenesis of hemorrhoids.
• Strategies focused on adiposity reduction may be crucial for mitigating hemorrhoid risk.