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Updated: Jul 12, 2025
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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
10.4K
Familial Risk and Interaction With Smoking and Alcohol Consumption in Bladder Cancer: A Population-Based Cohort
Hyun Jung Kim1, Kyoung-Hoon Kim2, Sung Won Lee3
1Department of Preventive Medicine, College of Medicine, Korea University, Seoul 02841, Korea.
World Journal of Oncology
|October 23, 2023
Summary
Individuals with a family history of bladder cancer face increased risks, especially when combined with smoking. Genetic predisposition is a key factor, highlighting the need for genetic counseling for high-risk groups.
Area of Science:
- Oncology
- Genetics
- Epidemiology
Background:
- Genetic factors are implicated in bladder cancer development, but population-level familial risk data is limited.
- Understanding familial aggregation is crucial for risk stratification and prevention strategies.
Purpose of the Study:
- To quantify the familial risk of bladder cancer.
- To investigate interactions between a family history of bladder cancer and lifestyle factors like smoking and alcohol consumption.
Main Methods:
- A large cohort study (5,524,403 subjects) using the National Health Insurance database (2002-2019).
- Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to assess familial risk.
- Relative excess risk due to interaction (RERI) was used to evaluate gene-environment interactions.
Main Results:
- Offspring with an affected parent had a 2.09-fold increased risk of bladder cancer.
- A positive family history combined with smoking significantly increased disease risk (HR: 3.60), with a statistically significant interaction (RERI: 0.72).
- A family history also increased risk for alcohol consumers, though the interaction was not statistically significant.
Conclusions:
- Genetic predisposition appears to be the primary driver of familial bladder cancer aggregation.
- Smokers and alcohol consumers with a family history of bladder cancer represent a high-risk group.
- Genetic counseling is recommended for individuals with a family history and relevant lifestyle risk factors.
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