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Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Longitudinal Studies01:26

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

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HALL: a comprehensive database for human aging and longevity studies.

Hao Li1,2, Song Wu3,4,2, Jiaming Li1,2

  • 1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.

Nucleic Acids Research
|October 23, 2023
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Summary
This summary is machine-generated.

Researchers created the Human Aging and Longevity Landscape (HALL), a database of multi-omics data from diverse human cohorts. This resource aims to advance healthy aging research and identify longevity biomarkers.

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Area of Science:

  • Gerontology
  • Bioinformatics
  • Genomics

Background:

  • Human aging varies significantly, with centenarians representing models of healthy aging.
  • Rapid advancements in omics technologies have generated vast datasets on aging and longevity.
  • Existing data requires an integrated platform for comprehensive analysis.

Purpose of the Study:

  • To establish a comprehensive, multi-omics database for human aging and longevity research.
  • To provide a repository of biomarkers for assessing aging trajectories.
  • To support the development of diagnostic tools and interventions for longevity.

Main Methods:

  • Integration of diverse omics data (phenomics, genomics, transcriptomics, proteomics, metabolomics, microbiomics).
  • Inclusion of data from a wide spectrum of human cohorts, from young adults to centenarians.
  • Development of the Human Aging and Longevity Landscape (HALL) database.

Main Results:

  • The Human Aging and Longevity Landscape (HALL) database has been established.
  • HALL integrates multi-omics data across the human lifespan.
  • The database provides a resource for identifying aging biomarkers and facilitating research.

Conclusions:

  • HALL serves as a crucial resource for advancing the understanding of human aging and longevity.
  • The database will aid in developing strategies for promoting healthy aging and enhancing lifespan.
  • Public accessibility of HALL promotes collaborative research in gerontology.