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Conference report: WHO meeting summary on mRNA-based tuberculosis vaccine development
Monika M Looney1, Mark Hatherill1, Munyaradzi Musvosvi1
1South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Vaccine
|October 23, 2023
Summary
Messenger RNA (mRNA) vaccines show promise for accelerating the development of new tuberculosis (TB) vaccines. Global experts convened to discuss the feasibility and potential of mRNA technology to combat TB, a significant global health challenge.
Area of Science:
- Vaccinology
- Infectious Diseases
- Molecular Biology
Background:
- Tuberculosis (TB) remains a critical global health emergency, with billions infected by Mycobacterium tuberculosis (Mtb).
- In 2021, TB caused 10.6 million new cases and 1.6 million deaths, highlighting an urgent need for effective interventions.
- Development of highly effective TB vaccines has been slow and under-resourced, necessitating novel approaches.
Purpose of the Study:
- To evaluate the feasibility and potential value of messenger RNA (mRNA) vaccine technology for tuberculosis.
- To discuss the current TB vaccine pipeline, novel antigen identification, and correlates of protection.
- To explore clinical development strategies, community acceptance, and manufacturing considerations for mRNA TB vaccines.
Main Methods:
- Convening of World Health Organization (WHO) global experts in April 2023.
- Review of expert presentations and panel discussions on mRNA vaccine technology for TB.
- Deliberations on vaccine pipeline, novel antigens, correlates of protection, clinical strategy, and community acceptance.
Main Results:
- The mRNA vaccine platform presents a potential opportunity to accelerate the development of new TB vaccines.
- Discussions covered key aspects including novel antigens, correlates of protection, and clinical development pathways.
- Considerations for community acceptance, ethical implications, and manufacturing capacity building were addressed.
Conclusions:
- mRNA-based vaccines are a potentially powerful new tool to help reduce the global burden of tuberculosis.
- The meeting underscored the importance of industry collaboration, transparency, and global responsibility in TB vaccine development.
- Further research and development are crucial to harness the potential of mRNA technology against TB.
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