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ATG12-ATG5-TECPR1: an alternative E3-like complex utilized during the cellular response to lysosomal membrane damage

Dale P Corkery1,2, Yao-Wen Wu1,2

  • 1SciLifeLab and Department of Chemistry, Umeå University, Umeå, Sweden.

Autophagy
|October 24, 2023
PubMed
Summary

Researchers discovered a new E3-like complex for lysosomal repair. This complex, independent of ATG16L1, uses TECPR1 to target damaged membranes, regulating LC3 lipidation and promoting repair.

Keywords:
ESCRTTECPR1lysophagylysosomemembrane repair

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