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TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

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Sea squirt-inspired bio-derived tissue sealants.

Aishwarya V Menon, Jessica E Torres, Abigail D Cox

Biorxiv : the Preprint Server for Biology

|October 24, 2023

Summary

Inspired by sea squirts, researchers developed a bio-based tissue sealant from plant protein and tannic acid. This low-cost, biodegradable sealant effectively seals wounds, showing potential to replace current surgical adhesives.

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Area of Science:

Biomaterials Science
Tissue Engineering
Marine Biology Inspiration

Background:

Current surgical adhesives often rely on petroleum products, lacking biodegradability and affordability.
Existing sealants can involve complex synthesis, limiting accessibility and increasing costs.
Sea squirts utilize gallol-protein crosslinking for natural wound healing.

Approach:

Developed a bio-based tissue sealant using zein (plant protein) and tannic acid (polyphenol).
Investigated sealant performance with and without the enzyme transglutaminase.
Evaluated adhesion strength across nine tissue substrates and compared with FDA-approved fibrin sealant (Tisseel).

Key Points:

Sealant adhesion exceeded physiological pressures on most tested substrates.
Demonstrated rapid wound sealing (<1 minute) in ex vivo models.
Achieved cytocompatibility and effective in vivo wound healing in rat models, comparable to sutures and Tisseel.

Conclusions:

The developed bio-based sealant offers a low-cost, easily synthesized alternative to conventional surgical adhesives.
Sea squirt-inspired mechanism provides a novel approach for effective wound closure.
This sealant shows significant potential to advance wound management and surgical practices.