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Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

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Updated: Jun 21, 2026

Isolation and Characterization of RNA-Containing Exosomes

Isolation and Characterization of RNA-Containing Exosomes

Published on: January 9, 2012

Exploring the Versatility of Exosomes: A Review on Isolation, Characterization, Detection Methods, and Diverse

Özge Altıntaş¹, Yeşeren Saylan¹

¹Hacettepe University, Department of Chemistry, 06800 Ankara, Turkey.

Analytical Chemistry

|October 24, 2023

Summary

This review summarizes exosome research, focusing on isolation, characterization, and applications. Exosome detection using sensors is highlighted for developing point-of-care diagnostic tools.

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Last Updated: Jun 21, 2026

Isolation and Characterization of RNA-Containing Exosomes

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Published on: January 9, 2012

Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile

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Published on: June 13, 2016

Isolation and Characterization of Exosomes from Skeletal Muscle Fibroblasts

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Published on: May 16, 2020

Area of Science:

Biotechnology
Cell Biology
Nanomedicine

Background:

Extracellular vesicles (EVs) mediate intercellular communication.
Exosomes, a type of EV, show promise as diagnostic and therapeutic tools.
Exosomes are released from cells through specific mechanisms.

Purpose of the Study:

To provide a comprehensive overview of exosome research.
To detail exosome isolation and characterization techniques.
To explore exosome applications in diagnostics and therapeutics.

Main Methods:

Differential ultracentrifugation
Immune affinity capture
Ultrafiltration
Size exclusion chromatography

Main Results:

Exosomes can be isolated from various biofluids.
Diverse methods exist for exosome characterization.
Exosome detection is advancing with sensor technologies.

Conclusions:

Exosome research is rapidly evolving.
Sensor-based detection offers potential for point-of-care diagnostics.
Exosomes hold significant promise for future medical applications.