Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular Dynamics Simulations of Polyelectrolyte Complexes.

Biomacromolecules·2024
Same author

Deciphering the Role of π-Interactions in Polyelectrolyte Complexes Using Rationally Designed Peptides.

Polymers·2021
Same author

Structural transitions and encapsulation selectivity of thermoresponsive polyelectrolyte complex micelles.

Journal of materials chemistry. B·2019
Same author

Engineering Peptide-Based Polyelectrolyte Complexes with Increased Hydrophobicity.

Molecules (Basel, Switzerland)·2019
Same journal

Reaction Optimization for Enzymatic Deconstruction of Industrially Relevant Nylon Composites.

Chembiochem : a European journal of chemical biology·2026
Same journal

Deploying Artificial Metalloenzymes in Complex Environments: Strategies and Applications.

Chembiochem : a European journal of chemical biology·2026
Same journal

Synthetic Ligands of Myeloid C-Type Lectin Receptors.

Chembiochem : a European journal of chemical biology·2026
Same journal

Vancomycin-Mediated Binding of DNA Origami Nanostructures to Gram-Positive and Gram-Negative Bacteria.

Chembiochem : a European journal of chemical biology·2026
Same journal

Mutasynthesis and Antibiotic Activity of Mupirocin Analogues.

Chembiochem : a European journal of chemical biology·2026
Same journal

Pressure-Dependent Aromatic Ring Flips Reveal Variable Transition-State Volume and Compressibility Among Structural Regions of BPTI.

Chembiochem : a European journal of chemical biology·2026
See all related articles

Related Experiment Video

Updated: Jul 12, 2025

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

10.8K

Drug Encapsulation via Peptide-Based Polyelectrolyte Complexes.

Sara Tabandeh1, Tahoora Ateeq1, Lorraine Leon1,2

  • 1Department of Materials Science and Engineering, University of Central Florida, 12760 Pegasus Dr, Orlando, FL-32816, USA.

Chembiochem : a European Journal of Chemical Biology
|October 24, 2023
PubMed
Summary
This summary is machine-generated.

Peptide polyelectrolyte complexes efficiently encapsulate drugs like doxorubicin and methylene blue. Higher charge density and hydrophobicity in peptide sequences enhance drug loading and complex stability for drug delivery applications.

Keywords:
coacervateencapsulationpolyelectrolyte complexpolypeptideself-assembly

More Related Videos

Author Spotlight: Tackling Challenges in Synthetic Cell Engineering
10:56

Author Spotlight: Tackling Challenges in Synthetic Cell Engineering

Published on: April 12, 2024

1.1K
Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
10:01

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Published on: April 8, 2020

5.9K

Related Experiment Videos

Last Updated: Jul 12, 2025

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

10.8K
Author Spotlight: Tackling Challenges in Synthetic Cell Engineering
10:56

Author Spotlight: Tackling Challenges in Synthetic Cell Engineering

Published on: April 12, 2024

1.1K
Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
10:01

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Published on: April 8, 2020

5.9K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Peptide-based polyelectrolyte complexes offer tunable properties for encapsulating diverse molecules.
  • Understanding molecular interactions is key to designing effective drug delivery carriers.

Purpose of the Study:

  • To investigate the encapsulation efficiency and stability of model drugs within rationally designed polypeptide sequences.
  • To elucidate the role of charge density and hydrophobicity in peptide-drug interactions and complex formation.

Main Methods:

  • UV-Vis spectroscopy
  • Fluorescence microscopy
  • Infrared spectroscopy

Main Results:

  • Encapsulation efficiency increased with higher peptide charge density due to ionic interactions.
  • Hydrophobicity significantly enhanced encapsulation of both doxorubicin (DOX) and methylene blue (MB) at similar charge densities.
  • Methylene blue encapsulation altered complex stability, leading to a liquid-to-solid phase change in highly charged and hydrophobic sequences.

Conclusions:

  • Both ionic and hydrophobic interactions are crucial for efficient encapsulation of poorly soluble drugs.
  • Polypeptide sequence design, balancing charge density and hydrophobicity, can control drug loading and the physical properties of delivery complexes.
  • These findings provide insights for developing advanced peptide-based drug delivery carriers.