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The Need for Fiber Addition in Symptomatic Heart Failure (FEAST-HF): A Randomized Controlled Pilot Trial
Eloisa Colin-Ramirez1, Wendimagegn Alemayehu2, Finlay A McAlister2,3
1Universidad Anáhuac México, Huixquilucan, Mexico.
CJC Open
|October 25, 2023
Summary
Supplementing symptomatic heart failure patients with acacia fiber was safe and well-tolerated but did not improve key biomarkers or alter the gut microbiome. Further research is needed to explore fiber
Area of Science:
- Cardiology
- Gastroenterology
- Microbiome Research
Background:
- Preclinical and observational studies suggest a role for the gut microbiome in heart failure (HF) pathogenesis.
- Fermentable dietary fiber (FDF) may modify the gut microbiome.
- The FEAST-HF trial investigated FDF supplementation in HF patients.
Purpose of the Study:
- To evaluate the feasibility of recruiting and supplementing HF patients with FDF.
- To determine if FDF (acacia) reduces NT-proBNP and ST2 levels compared to a control.
- To assess the impact of FDF on the gut microbiome composition.
Main Methods:
- Randomized controlled trial with 51 patients allocated to microcrystalline cellulose (MCC), 5 g/day acacia, or 10 g/day acacia.
- Outcomes measured at baseline, 6, and 12 weeks included NT-proBNP, ST2, NYHA class, quality of life scores, and 6-minute walk test.
- Safety, tolerability, and adherence were monitored throughout the study.
Main Results:
- No significant differences in NT-proBNP, ST2, NYHA class, or quality of life scores were observed between acacia and MCC groups over 12 weeks.
- Dietary supplementation with acacia gum showed a negligible impact on gut microbial communities.
- No safety, tolerability, or adherence issues were reported for either acacia dose.
Conclusions:
- Dietary supplementation with acacia gum is safe and well-tolerated in ambulatory HF patients.
- Acacia gum supplementation did not significantly alter NT-proBNP levels, ST2, or gut microbiome composition.
- The FEAST-HF trial did not demonstrate a clinical benefit of acacia gum in this HF population.
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