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Published on: February 6, 2019
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Radiation therapy options in kidney cancer
Nicholas G Zaorsky1, Alexander V Louie2, Shankar Siva3
1University Hospitals Seidman Cancer Center and Case Western Reserve University, Cleveland, Ohio, USA.
Current Opinion in Supportive and Palliative Care
|October 25, 2023
Summary
Stereotactic body radiation therapy (SBRT) offers excellent local control for primary and metastatic renal cell carcinoma (RCC). This safe and effective treatment shows limited toxicity for patients with kidney cancer.
Area of Science:
- Oncology
- Radiation Oncology
Background:
- Renal cell carcinoma (RCC) presents challenges in primary and metastatic settings.
- Stereotactic body radiation therapy (SBRT) is an evolving treatment modality.
Approach:
- This review synthesizes current evidence on SBRT for primary and metastatic RCC.
- Examines efficacy, toxicity, and ongoing research.
Key Points:
- For primary RCC, SBRT achieves >95% local control with ≤5% grade 3-4 toxicity and minimal GFR impact.
- For metastatic RCC, SBRT demonstrates ~90% 1-year local control and ~1% grade 3-4 toxicity.
- Ongoing trials explore SBRT in combination with or as an alternative to systemic therapies.
Conclusions:
- SBRT is a safe and effective treatment for both primary and metastatic RCC.
- Further research is needed to address remaining unknowns in RCC prognostication, treatment selection, and delivery.
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