Potentially active compounds that improve PAD through angiogenesis: A review.

Area of Science:

• Cardiovascular Research
• Pharmacology
• Angiogenesis Therapeutics

Background:

• Peripheral arterial disease (PAD) incidence is rising due to atherosclerosis and diabetes.
• Historically, PAD has lacked effective pharmacological treatments.
• Angiogenesis promotion is a key strategy for improving PAD outcomes.

Purpose of the Study:

• To review natural and synthetic compounds for PAD treatment.
• To explore mechanisms of angiogenesis promotion by these compounds.
• To identify potential therapeutic agents for PAD.

Main Methods:

• Literature review of natural products (e.g., Salidroside, Astragaloside IV) and synthetic drugs (e.g., Cilostazol, Dapagliflozin).
• Analysis of compound effects on vascular endothelial cell autocrine and paracrine signaling.
• Investigation of compound impact on endothelial progenitor cell function.
• Exploration of underlying molecular pathways (e.g., PI3K, AMPK).

Main Results:

• Exogenous compounds demonstrate potential to promote angiogenesis in PAD.
• Compounds influence vascular endothelial cell communication and progenitor cell activity.
• PI3K and AMPK pathways are implicated in the therapeutic effects.

Conclusions:

• Natural and synthetic compounds offer promising therapeutic avenues for PAD.
• These agents provide diverse options for drug discovery in PAD treatment.
• Further research into these compounds could significantly benefit PAD patients.