Related Experiment Video
Updated: Jul 12, 2025
07:14
A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
Published on: January 18, 2018
9.4K
Assessing the Content Validity of Preference-Based Measures in Cancer
Adam E J Gibson1, Louise Longworth1, Bryan Bennett2
1Putnam PHMR Ltd, London, England, UK.
Summary
Condition-specific preference-based measures (PBMs) showed better relevancy for cancer patients than generic PBMs. The FACT-8D demonstrated the best content validity, informing oncology measurement strategies.
Area of Science:
- Oncology
- Health Outcomes Research
- Psychometrics
Background:
- Preference-based measures (PBMs) are crucial for assessing health-related quality of life (HRQoL) in cancer care.
- Evaluating the content validity of generic and condition-specific PBMs is essential for informing oncology development programs and real-world applications.
Purpose of the Study:
- To assess the content validity of generic and condition-specific PBMs using patient perspectives.
- To evaluate PBMs against the Consensus-Based Standards for the Selection of Health Measurement Instruments criteria.
Main Methods:
- Individual, semistructured interviews with 96 cancer patients in the UK and US.
- Patients completed 3 generic PBMs and 2 condition-specific PBMs.
- Thematic and content analysis of interview transcripts.
Main Results:
- Condition-specific PBMs were rated as more relevant than generic PBMs.
- The Functional Assessment of Cancer Therapy Eight Dimension (FACT-8D) showed the highest content validity for relevancy.
- The EQ-5D-5L was rated highest for comprehensibility, with FACT-8D and Quality of Life Utility-Core 10 Dimension also performing well.
Conclusions:
- While generally adequate, PBMs need further development, especially for long-term cancer impacts and treatment side effects.
- Future instruments should incorporate conventional health, treatment impacts, and psychological items for comprehensive cancer HRQoL assessment.
More Related Videos
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
296
06:28E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
8.4K
Related Concept Videos
01:21Cancer Survival Analysis
357
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
357
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
02:43Mouse Models of Cancer Study
5.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.6K
02:18Cancer
48.6K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
48.6K
02:12What is Cancer?
10.8K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
10.8K