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Selenium Species in Diabetes Mellitus Type 2.
Krystyna Pyrzynska1, Aleksandra Sentkowska2
1Faculty of Chemistry, University of Warsaw, Pasteur Str. 1, 02-093, Warsaw, Poland. kryspyrz@chem.uw.edu.pl.
Biological Trace Element Research
|October 25, 2023
Summary
Selenium
Area of Science:
- Nutritional Biochemistry
- Metabolic Pathways
Background:
- Selenium (Se) is a vital trace element for human and animal metabolism.
- Its role in diabetes mellitus (DM), especially type 2 (T2DM), is complex and debated.
- Existing research presents contradictory findings on selenium's impact on T2DM risk.
Purpose of the Study:
- To review recent findings on selenium's role in diabetes mellitus.
- To elucidate the dose-dependent and chemical form-specific relationship between selenium and T2DM risk.
Main Methods:
- Literature review of recent studies on selenium and diabetes.
- Analysis of the dose-response relationship and chemical forms of selenium.
- Consideration of baseline selenium status.
Main Results:
- A non-linear, U-shaped relationship exists between selenium levels and T2DM risk.
- Both insufficient and excessive selenium intake can elevate diabetes risk.
- The chemical form of selenium influences its metabolic effects and T2DM risk.
Conclusions:
- Selenium's influence on T2DM is dose-dependent and form-specific.
- Maintaining optimal selenium levels is crucial for diabetes prevention.
- Individual baseline selenium status is essential to guide supplementation and avoid adverse effects.
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